Canertinib dihydrochloride
- Product Name
- Canertinib dihydrochloride
- CAS No.
- 289499-45-2
- Chemical Name
- Canertinib dihydrochloride
- Synonyms
- CI103;CI 103;CI-1033;Canertinib HCl;Canertinib 2HC;Canertinib.2HCL;CI1033 dihydrochloride;CI 1033 dihydrochloride;CI-1033 dihydrochloride;Canertinib (CI-1033) HCl
- CBNumber
- CB11011729
- Molecular Formula
- C24H27Cl3FN5O3
- Formula Weight
- 558.86
- MOL File
- 289499-45-2.mol
Canertinib dihydrochloride Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: >10mg/mL
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7249
- Product name
- CI-1033
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $86.8
- Updated
- 2024/03/01
- Product number
- C7249
- Product name
- CI-1033
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $351
- Updated
- 2024/03/01
- Product number
- 12076
- Product name
- Canertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 12076
- Product name
- Canertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 12076
- Product name
- Canertinib (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $134
- Updated
- 2024/03/01
Canertinib dihydrochloride Chemical Properties,Usage,Production
Uses
CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
Uses
Canertinib Dihydrochloride is a water-soluble, EGFR, HER2, and ErbB-4 tyrosine kinase inhibitor.
Uses
The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.Canertinib dihydrochloride is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib dihydrochloride also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.
storage
Store at -20°C
Canertinib dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Canertinib dihydrochloride Suppliers
View Lastest Price from Canertinib dihydrochloride manufacturers
- Product
- Canertinib dihydrochloride 289499-45-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-08
- Product
- Canertinib dihydrochloride 289499-45-2
- Price
- US $23.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2021-12-16
- Product
- Canertinib dihydrochloride 289499-45-2
- Price
- US $19.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-12-28